Ontology highlight
ABSTRACT:
SUBMITTER: Le Naour A
PROVIDER: S-EPMC7181721 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Le Naour Augustin A Prat Mélissa M Thibault Benoît B Mével Renaud R Lemaitre Léa L Leray Hélène H Joubert Marie-Véronique MV Coulson Kimberley K Golzio Muriel M Lefevre Lise L Mery Eliane E Martinez Alejandra A Ferron Gwénaël G Delord Jean-Pierre JP Coste Agnès A Couderc Bettina B
Journal of molecular cell biology 20200401 3
Factors released by surrounding cells such as cancer-associated mesenchymal stromal cells (CA-MSCs) are involved in tumor progression and chemoresistance. In this study, we characterize the mechanisms by which naïve mesenchymal stromal cells (MSCs) can acquire a CA-MSCs phenotype. Ovarian tumor cells trigger the transformation of MSCs to CA-MSCs by expressing pro-tumoral genes implicated in the chemoresistance of cancer cells, resulting in the secretion of high levels of CXC chemokine receptors ...[more]