Ontology highlight
ABSTRACT:
SUBMITTER: Kim Y
PROVIDER: S-EPMC7181751 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Kim Yeonjoo Y Lee Jiyoung J Seppala Maisa M Cobourne Martyn T MT Kim Soo-Hyun SH
Nature communications 20200424 1
Gas1 and Boc/Cdon act as co-receptors in the vertebrate Hedgehog signalling pathway, but the nature of their interaction with the primary Ptch1/2 receptors remains unclear. Here we demonstrate, using primordial germ cell migration in mouse as a developmental model, that specific hetero-complexes of Ptch2/Gas1 and Ptch1/Boc mediate the process of Smo de-repression with different kinetics, through distinct modes of Hedgehog ligand reception. Moreover, Ptch2-mediated Hedgehog signalling induces the ...[more]