Ontology highlight
ABSTRACT:
SUBMITTER: Larsson I
PROVIDER: S-EPMC7181968 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Larsson Ida I Uhlén Mathias M Zhang Cheng C Mardinoglu Adil A
Frontiers in genetics 20200417
Glioblastoma (GBM) is an aggressive type of brain cancer with a poor prognosis for affected patients. The current line of treatment only gives the patients a survival time of on average 15 months. In this work, we use genome-scale metabolic models (GEMs) together with other systems biology tools to examine the global transcriptomics-data of GBM-patients obtained from The Cancer Genome Atlas (TCGA). We reveal the molecular mechanisms underlying GBM and identify potential therapeutic targets for e ...[more]