Ontology highlight
ABSTRACT:
SUBMITTER: Aalipour A
PROVIDER: S-EPMC7183102 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Molecular therapy oncolytics 20200407
Chimeric antigen receptor (CAR) T cell therapy has had limited efficacy for solid tumors, largely due to a lack of selectively and highly expressed surface antigens. To avoid reliance on a tumor's endogenous antigens, here we describe a method of tumor-selective delivery of surface antigens using an oncolytic virus to enable a generalizable CAR T cell therapy. Using CD19 as our proof of concept, we engineered a thymidine kinase-disrupted vaccinia virus to selectively deliver CD19 to malignant ce ...[more]