Ontology highlight
ABSTRACT:
SUBMITTER: de Semir D
PROVIDER: S-EPMC7183218 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
de Semir David D Bezrookove Vladimir V Nosrati Mehdi M Scanlon Kara R KR Singer Eric E Judkins Jonathon J Rieken Christopher C Wu Clayton C Shen Julia J Schmudermayer Christina C Dar Altaf A AA Miller James R JR Cobbs Charles C Yount Garret G Desprez Pierre-Yves PY Debs Robert J RJ Salomonis Nathan N McAllister Sean S Cleaver James E JE Soroceanu Liliana L Kashani-Sabet Mohammed M
Proceedings of the National Academy of Sciences of the United States of America 20200409 16
The invasive behavior of glioblastoma is essential to its aggressive potential. Here, we show that pleckstrin homology domain interacting protein (PHIP), acting through effects on the force transduction layer of the focal adhesion complex, drives glioblastoma motility and invasion. Immunofluorescence analysis localized PHIP to the leading edge of glioblastoma cells, together with several focal adhesion proteins: vinculin (VCL), talin 1 (TLN1), integrin beta 1 (ITGB1), as well as phosphorylated f ...[more]