Ontology highlight
ABSTRACT:
SUBMITTER: Noguchi M
PROVIDER: S-EPMC7183507 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Noguchi Masanori M Arai Gaku G Egawa Shin S Ohyama Chikara C Naito Seiji S Matsumoto Kazumasa K Uemura Hirotsugu H Nakagawa Masayuki M Nasu Yasutomo Y Eto Masatoshi M Suekane Shigetaka S Sasada Tetsuro T Shichijo Shigeki S Yamada Akira A Kakuma Tatsuyuki T Itoh Kyogo K
Cancer immunology, immunotherapy : CII 20200205 5
A novel cancer vaccine consisting of 20 mixed peptides (KRM-20) was designed to induce cytotoxic T lymphocytes (CTL) against twelve different tumor-associated antigens. The aim of this phase II trial was to examine whether KRM-20 in combination with docetaxel and dexamethasone enhances the antitumor effects in patients with castration-resistant prostate cancer (CRPC). In this double-blind, placebo-controlled, randomized phase II study, we enrolled chemotherapy-naïve patients with CRPC from ten m ...[more]