High-density lipoprotein cholesterol concentration and acute kidney injury after noncardiac surgery.

ABSTRACT:

Background

Abnormal High-density Lipoprotein Cholesterol Concentration is closely related to postoperative acute kidney injury (AKI) after cardiac surgeries. The purpose of this study was to analyze the relationship between High-density Lipoprotein Cholesterol Concentration and acute kidney injury after non-cardiac surgeries.

Method

This was a single-center cohort study for elective non-cardiac non-kidney surgery from January 1, 2012, to December 31, 2017. The endpoint was the occurrence of acute kidney injury (AKI) 7?days postoperatively in the hospital. Preoperative serum High-density Lipoprotein Cholesterol Concentration was examined by multivariate logistic regression models before and after propensity score weighting analysis.

Results

Of the 74,284 surgeries, 4.4% (3159 cases) suffered acute kidney injury. The odds ratio for HDL (0.96-1.14 as reference, ?1.35) was 1.28 (1.14-1.41), P??1.03 as reference) was associated with increased risk of postoperative AKI, with odds ratio 1.40 (1.27?~?1.52), P?ConclusionsUsing multivariate regression analyses before and after propensity score weighting, in addition to multiple sensitivity analysis methods, this study found that following non-cardiac surgery, low HDL cholesterol levels were independent risk factors for AKI.

SUBMITTER: Zhou Y 

PROVIDER: S-EPMC7183648 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature