Unknown

Dataset Information

0

Prevalence of familial cluster headache: a systematic review and meta-analysis.


ABSTRACT:

Introduction

The population rate of familial cluster headache (CH) has been reported to be as high as 20% however this varies considerably across studies. To obtain a true estimate of family history in CH, we conducted a systematic review and meta-analysis of previously published data.

Methods

Our systematic review involved a search of electronic databases (Medline, EMBASE, PubMed, CINAHL) to identify and appraise studies of interest utilising the PRISMA (Preferred Reporting Items for Systematic Review and Meta-Analysis) guidelines. To further ameliorate the accuracy of our analysis we included an additional unpublished cohort of CH patients recruited at a tertiary referral centre for headache, who underwent detailed family history with diagnostic verification in relatives. Data was extracted and meta-analysis conducted to provide a true estimation of family history.

Results

In total, we identified 7 studies which fulfilled our inclusion criteria. The estimated true prevalence of CH patients with a positive family history was 6.27% (95% CI:4.65-8.40%) with an overall I2 of 73%. Fitted models for gender subgroups showed higher estimates 9.26% (95% CI: 6.29-13.43%) in females. However the I2 for the female model was 58.42% and significant (p?=?0.047).

Conclusion

Our findings estimate a rate of family history in CH to be approximately 6.27% (95% CI: 4.65-8.40%). While estimates were larger for female probands, we demonstrated high heterogeneity in this subgroup. These findings further support a genetic role in the aetiology of CH.

SUBMITTER: O'Connor E 

PROVIDER: S-EPMC7183702 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature

altmetric image

Publications

Prevalence of familial cluster headache: a systematic review and meta-analysis.

O'Connor Emer E   Simpson Benjamin S BS   Houlden Henry H   Vandrovcova Jana J   Matharu Manjit M  

The journal of headache and pain 20200425 1


<h4>Introduction</h4>The population rate of familial cluster headache (CH) has been reported to be as high as 20% however this varies considerably across studies. To obtain a true estimate of family history in CH, we conducted a systematic review and meta-analysis of previously published data.<h4>Methods</h4>Our systematic review involved a search of electronic databases (Medline, EMBASE, PubMed, CINAHL) to identify and appraise studies of interest utilising the PRISMA (Preferred Reporting Items  ...[more]

Similar Datasets

| S-EPMC8911224 | biostudies-literature
| S-EPMC5588988 | biostudies-literature
| S-EPMC8237453 | biostudies-literature
| S-EPMC7644512 | biostudies-literature
| S-EPMC9218408 | biostudies-literature
| S-EPMC7011689 | biostudies-literature
| S-EPMC6603699 | biostudies-literature
| 79216 | ecrin-mdr-crc
| S-EPMC5549151 | biostudies-other
| S-EPMC7728918 | biostudies-literature