Ontology highlight
ABSTRACT:
SUBMITTER: Ozaki E
PROVIDER: S-EPMC7184027 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Ozaki Ema E Gibbons Luke L Neto Nuno Gb NG Kenna Paul P Carty Michael M Humphries Marian M Humphries Pete P Campbell Matthew M Monaghan Michael M Bowie Andrew A Doyle Sarah L SL
Life science alliance 20200420 5
Retinal degeneration is the leading cause of incurable blindness worldwide and is characterised by progressive loss of light-sensing photoreceptors in the neural retina. SARM1 is known for its role in axonal degeneration, but a role for SARM1 in photoreceptor cell degeneration has not been reported. SARM1 is known to mediate neuronal cell degeneration through depletion of essential metabolite NAD and induction of energy crisis. Here, we demonstrate that SARM1 is expressed in photoreceptors, and ...[more]