Ontology highlight
ABSTRACT:
SUBMITTER: Bilska A
PROVIDER: S-EPMC7184606 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Nature communications 20200427 1
TENT5C is a non-canonical cytoplasmic poly(A) polymerase highly expressed by activated B cells to suppress their proliferation. Here we measure the global distribution of poly(A) tail lengths in responsive B cells using a Nanopore direct RNA-sequencing approach, showing that TENT5C polyadenylates immunoglobulin mRNAs regulating their half-life and consequently steady-state levels. TENT5C is upregulated in differentiating plasma cells by innate signaling. Compared with wild-type, Tent5c<sup>-/-</ ...[more]