Ontology highlight
ABSTRACT:
SUBMITTER: Trembinski DJ
PROVIDER: S-EPMC7184724 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Nature communications 20200427 1
Long non-coding RNAs (lncRNAs) contribute to cardiac (patho)physiology. Aging is the major risk factor for cardiovascular disease with cardiomyocyte apoptosis as one underlying cause. Here, we report the identification of the aging-regulated lncRNA Sarrah (ENSMUST00000140003) that is anti-apoptotic in cardiomyocytes. Importantly, loss of SARRAH (OXCT1-AS1) in human engineered heart tissue results in impaired contractile force development. SARRAH directly binds to the promoters of genes downregul ...[more]