Aging-regulated anti-apoptotic long non-coding RNA Sarrah augments recovery from acute myocardial infarction.
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ABSTRACT:
SUBMITTER: Trembinski DJ
PROVIDER: S-EPMC7184724 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Publications
Aging-regulated anti-apoptotic long non-coding RNA Sarrah augments recovery from acute myocardial infarction.
Trembinski D Julia DJ Bink Diewertje I DI Theodorou Kosta K Sommer Janina J Fischer Ariane A van Bergen Anke A Kuo Chao-Chung CC Costa Ivan G IG Schürmann Christoph C Leisegang Matthias S MS Brandes Ralf P RP Alekseeva Tijna T Brill Boris B Wietelmann Astrid A Johnson Christopher N CN Spring-Connell Alexander A Kaulich Manuel M Werfel Stanislas S Engelhardt Stefan S Hirt Marc N MN Yorgan Kaja K Eschenhagen Thomas T Kirchhof Luisa L Hofmann Patrick P Jaé Nicolas N Wittig Ilka I Hamdani Nazha N Bischof Corinne C Krishnan Jaya J Houtkooper Riekelt H RH Dimmeler Stefanie S Boon Reinier A RA
Nature communications 20200427 1
Long non-coding RNAs (lncRNAs) contribute to cardiac (patho)physiology. Aging is the major risk factor for cardiovascular disease with cardiomyocyte apoptosis as one underlying cause. Here, we report the identification of the aging-regulated lncRNA Sarrah (ENSMUST00000140003) that is anti-apoptotic in cardiomyocytes. Importantly, loss of SARRAH (OXCT1-AS1) in human engineered heart tissue results in impaired contractile force development. SARRAH directly binds to the promoters of genes downregul ...[more]
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