Relationship Between Venules and Perivascular Spaces in Sporadic Small Vessel Diseases.

ABSTRACT: Background and Purpose- Perivascular spaces (PVS) around venules may help drain interstitial fluid from the brain. We examined relationships between suspected venules and PVS visible on brain magnetic resonance imaging. Methods- We developed a visual venular quantification method to examine the spatial relationship between venules and PVS. We recruited patients with lacunar stroke or minor nondisabling ischemic stroke and performed brain magnetic resonance imaging and retinal imaging. We quantified venules on gradient echo or susceptibility-weighted imaging and PVS on T2-weighted magnetic resonance imaging in the centrum semiovale and then determined overlap between venules and PVS. We assessed associations between venular count and patient demographic characteristics, vascular risk factor

SUBMITTER: Jochems ACC 

PROVIDER: S-EPMC7185057 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature