Ontology highlight
ABSTRACT:
SUBMITTER: Lu H
PROVIDER: S-EPMC7185217 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Lu Huimin H Shi Tongguo T Wang Mingyuan M Li Xiaomi X Gu Yanzheng Y Zhang Xueguang X Zhang Guangbo G Chen Weichang W
Oncoimmunology 20200414 1
The immunoregulatory protein B7-H3, a member of the B7 family, has been confirmed to be highly expressed in colon cancer. However, the exact influence of B7-H3 on the features and antitumor ability of γδT cells in colon cancer remains unknown. In the present study, we investigated that the proportions of B7-H3<sup>+</sup> γδT cells were distinctly increased in the peripheral blood and tumor tissues of colon cancer patients. B7-H3 blockade or knockdown promoted proliferation, inhibited cell apopt ...[more]