Ontology highlight
ABSTRACT:
SUBMITTER: Li L
PROVIDER: S-EPMC7185373 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
Li Liang L Chong Han Chung HC Ng Say Yong SY Kwok Ka Wai KW Teo Ziqiang Z Tan Eddie Han Pin EHP Choo Chee Chong CC Seet Ju Ee JE Choi Hyung Won HW Buist Martin Lindsay ML Chow Vincent Tak Kwong VTK Tan Nguan Soon NS
Cell reports 20150205 5
Excessive host inflammatory responses negatively impact disease outcomes in respiratory infection. Host-pathogen interactions during the infective phase of influenza are well studied, but little is known about the host's response during the repair stage. Here, we show that influenza infection stimulated the expression of angiopoietin-like 4 (ANGPTL4) via a direct IL6-STAT3-mediated mechanism. ANGPTL4 enhanced pulmonary tissue leakiness and exacerbated inflammation-induced lung damage. Treatment ...[more]