Identification of aberrantly methylated differentially expressed genes targeted by differentially expressed miRNA in osteosarcoma.
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ABSTRACT:
SUBMITTER: Wang TX
PROVIDER: S-EPMC7186728 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Publications
Identification of aberrantly methylated differentially expressed genes targeted by differentially expressed miRNA in osteosarcoma.
Wang Ting-Xuan TX Tan Wen-Le WL Huang Jin-Cheng JC Cui Zhi-Fei ZF Liang Ri-Dong RD Li Qing-Chu QC Lu Hai H
Annals of translational medicine 20200301 6
<h4>Background</h4>Osteosarcoma (OS) is the most common primary bone tumors diagnosed in children and adolescents. Recent studies have shown a prognostic role of DNA methylation in various cancers, including OS. The aim of this study was to identify the aberrantly methylated genes that are prognostically relevant in OS.<h4>Methods</h4>The differentially expressed mRNAs, miRNAs and methylated genes (DEGs, DEMs and DMGs respectively) were screened from various GEO databases, and the potential targ ...[more]
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