Identification of aberrantly methylated differentially expressed genes targeted by differentially expressed miRNA in osteosarcoma.

ABSTRACT:

Background

Osteosarcoma (OS) is the most common primary bone tumors diagnosed in children and adolescents. Recent studies have shown a prognostic role of DNA methylation in various cancers, including OS. The aim of this study was to identify the aberrantly methylated genes that are prognostically relevant in OS.

Methods

The differentially expressed mRNAs, miRNAs and methylated genes (DEGs, DEMs and DMGs respectively) were screened from various GEO databases, and the potential target genes of the DEMs were predicted by the RNA22 program. The protein-protein interaction (PPI) networks were constructed using the STRING database and visualized by Cytoscape software. The functional enrichment and survival analyses of the screened genes was performed using the R software.

Resul

SUBMITTER: Wang TX 

PROVIDER: S-EPMC7186728 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature