Reconstructing the Phylogeny of Corynebacteriales while Accounting for Horizontal Gene Transfer.

ABSTRACT: Horizontal gene transfer is a common mechanism in Bacteria that has contributed to the genomic content of existing organisms. Traditional methods for estimating bacterial phylogeny, however, assume only vertical inheritance in the evolution of homologous genes, which may result in errors in the estimated phylogenies. We present a new method for estimating bacterial phylogeny that accounts for the presence of genes acquired by horizontal gene transfer between genomes. The method identifies and corrects putative transferred genes in gene families, before applying a gene tree-based summary method to estimate bacterial species trees. The method was applied to estimate the phylogeny of the order Corynebacteriales, which is the largest clade in the phylum Actinobacteria. We report a collection o

SUBMITTER: Coimbra NDR 

PROVIDER: S-EPMC7186787 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature