Ontology highlight
ABSTRACT:
SUBMITTER: Love C
PROVIDER: S-EPMC7187140 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Love Celina C Steinkühler Jan J Gonzales David T DT Yandrapalli Naresh N Robinson Tom T Dimova Rumiana R Tang T-Y Dora TD
Angewandte Chemie (International ed. in English) 20200226 15
In situ, reversible coacervate formation within lipid vesicles represents a key step in the development of responsive synthetic cellular models. Herein, we exploit the pH responsiveness of a polycation above and below its pK<sub>a</sub> , to drive liquid-liquid phase separation, to form single coacervate droplets within lipid vesicles. The process is completely reversible as coacervate droplets can be disassembled by increasing the pH above the pK<sub>a</sub> . We further show that pH-triggered ...[more]