TINCR is not a non-coding RNA but encodes a protein component of cornified epidermal keratinocytes.
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ABSTRACT:
SUBMITTER: Eckhart L
PROVIDER: S-EPMC7187231 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Publications
TINCR is not a non-coding RNA but encodes a protein component of cornified epidermal keratinocytes.
Eckhart Leopold L Lachner Julia J Tschachler Erwin E Rice Robert H RH
Experimental dermatology 20200218 4
Long non-coding RNAs have been implicated in the regulation of a plethora of biological processes, yet it has been challenging to verify that they are truly not coding for proteins. Terminal differentiation-induced non-coding RNA (TINCR) is a 3.7-kilobase mRNA that is highly abundant in epidermal keratinocytes prior to cornification. Here, we report the presence of an evolutionarily conserved open reading frame in TINCR and the identification of peptides derived from this open reading frame in t ...[more]
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