Orchestrating mitochondria in neurons: Cytoskeleton as the conductor.
Ontology highlight
ABSTRACT:
SUBMITTER: Cardanho-Ramos C
PROVIDER: S-EPMC7187307 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Publications
Orchestrating mitochondria in neurons: Cytoskeleton as the conductor.
Cardanho-Ramos Carlos C Faria-Pereira Andreia A Morais Vanessa Alexandra VA
Cytoskeleton (Hoboken, N.J.) 20191209 3-4
Mitochondria are crucial to support synaptic activity, particularly through ATP production and Ca<sup>2+</sup> homeostasis. This implies that mitochondria need to be well distributed throughout the different neuronal sub-compartments. To achieve this, a tight and precise regulation of several neuronal cytoskeleton players is necessary to transport and dock mitochondria. As post-mitotic cells, neurons are highly dependent on mitochondrial quality control mechanisms and several cytoskeleton protei ...[more]
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