Ontology highlight
ABSTRACT:
SUBMITTER: Bischoff M
PROVIDER: S-EPMC7187416 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Chemistry (Weinheim an der Bergstrasse, Germany) 20200219 21
6-, 7-, and 8-membered rings are assembled from a linear precursor by successive cyclisation reactions to construct a tricyclic diazatricyclo[6.5.1.0<sup>4, 9</sup> ]-tetradecanedione scaffold. Advanced building blocks based on d-aspartic acid and l-pyroglutamic acid were combined by a sp<sup>3</sup> -sp<sup>2</sup> Negishi coupling. A carbamate-guided syn-diastereoselective epoxidation followed by an intramolecular epoxide opening allowed the construction of the piperidine ring. An efficient on ...[more]