Ontology highlight
ABSTRACT:
SUBMITTER: Lucchesi A
PROVIDER: S-EPMC7187459 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Lucchesi Alessandro A Carloni Silvia S De Matteis Serena S Ghetti Martina M Musuraca Gerardo G Poggiaspalla Monica M Augello Accursio F AF Giordano Giulio G Fattori Pier P PP Martinelli Giovanni G Napolitano Roberta R
British journal of haematology 20191202 2
This study was conducted to evaluate the expression of fibrinogen receptors on platelets of Philadelphia-negative chronic myeloproliferative neoplasm (MPN) patients. We collected blood samples from 40 consecutive MPN patients and healthy volunteers. We performed flow cytometry analysis of P-selectin expression and integrin beta-3, activation of glycoprotein (GP) IIb/IIIa and fibrinogen receptor exposure (PAC-1 binding). Surprisingly, we found a very low PAC-1 binding capacity in MPN patients; ho ...[more]