Emergence of an NDM-5-Producing Hypervirulent Klebsiella pneumoniae Sequence Type 35 Strain with Chromosomal Integration of an Integrative and Conjugative Element, ICEKp1.
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ABSTRACT:
SUBMITTER: Shen Z
PROVIDER: S-EPMC7187603 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
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Emergence of an NDM-5-Producing Hypervirulent Klebsiella pneumoniae Sequence Type 35 Strain with Chromosomal Integration of an Integrative and Conjugative Element, ICE<i>Kp1</i>.
Shen Zhen Z Gao Qianqian Q Qin Juanxiu J Liu Yao Y Li Min M
Antimicrobial agents and chemotherapy 20191220 1
Here, we report an NDM-5-producing sequence type 35 (ST35) hypervirulent <i>Klebsiella pneumoniae</i> strain, isolated from the blood of a male patient. It showed a remarkable resistance to serum killing and neutrophil phagocytosis and high virulence in a mouse peritonitis infection model. Instead of carrying a pLVPK-like virulence plasmid, chromosomal integration of ICE<i>Kp1</i> (∼76 kb) was identified in a specific asparagine-tRNA gene, harboring the iron acquisition system salmochelin genes ...[more]
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