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Antiretroviral Penetration across Three Preclinical Animal Models and Humans in Eight Putative HIV Viral Reservoirs.

ABSTRACT: For HIV cure strategies like "kick and kill" to succeed, antiretroviral (ARV) drugs must reach effective concentrations in putative viral reservoirs. We characterize penetration of six ARVs in three preclinical animal models and humans. We found that standard dosing strategies in preclinical species closely mimicked tissue concentrations in humans for some, but not all, ARVs. These results have implications for interpreting HIV treatment, prevention, or cure interventions between preclinical and clinical models.

SUBMITTER: Devanathan AS

PROVIDER: S-EPMC7187610 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature

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Antiretroviral Penetration across Three Preclinical Animal Models and Humans in Eight Putative HIV Viral Reservoirs.

Devanathan Aaron S AS Pirone Jason R JR Akkina Ramesh R Remling-Mulder Leila L Luciw Paul P Adamson Lourdes L Garcia J Victor JV Kovarova Martina M White Nicole R NR Schauer Amanda P AP Blake Kimberly K Sykes Craig C Burgunder Erin M EM Srinivas Nithya N Rosen Elias P EP Kashuba Angela D M ADM

Antimicrobial agents and chemotherapy 20191220 1

For HIV cure strategies like "kick and kill" to succeed, antiretroviral (ARV) drugs must reach effective concentrations in putative viral reservoirs. We characterize penetration of six ARVs in three preclinical animal models and humans. We found that standard dosing strategies in preclinical species closely mimicked tissue concentrations in humans for some, but not all, ARVs. These results have implications for interpreting HIV treatment, prevention, or cure interventions between preclinical and ...[more]

PMID: 31611355

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