The CaMKII phosphorylation site Thr1604 in the Ca_V1.2 channel is involved in pathological myocardial hypertrophy in rats.

ABSTRACT: Residue Thr1604 in the Ca_V1.2 channel is a Ca²⁺/calmodulin dependent protein kinase II (CaMKII) phosphorylation site, and its phosphorylation status maintains the basic activity of the channel. However, the role of Ca_V1.2 phosphorylation at Thr1604 in myocardial hypertrophy is incompletely understood. Isoproterenol (ISO) was used to induce cardiomyocyte hypertrophy, and autocamtide-2-related inhibitory peptide (AIP) was added as a treatment. Rats in a myocardial hypertrophy development model were subcutaneously injected with ISO for two or three weeks. The heart and left ventricle weights, each of which were normalized to the body weight and cross-sectional area of the myocardial cells, were used to describe the degree of hypertrophy. Protein expression lev

SUBMITTER: Li J 

PROVIDER: S-EPMC7188351 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature