Ontology highlight
ABSTRACT:
SUBMITTER: Miller A
PROVIDER: S-EPMC7188389 | biostudies-literature | 2020 Jan-Dec
REPOSITORIES: biostudies-literature
Miller Ami A Carr Stephen S Rabbitts Terry T Ali Hanif H
mAbs 20200101 1
The success of therapeutic antibodies is largely attributed for their exquisite specificity, homogeneity, and functionality. There is, however, a need to engineer antibodies to extend and enhance their potency. One parameter is functional affinity augmentation, since antibodies matured in vivo have a natural affinity threshold. Generation of multivalent antibodies is one option capable of surpassing this affinity threshold through increased avidity. In this study, we present a novel platform con ...[more]