Effect of Very Low-Dose Hydrocortisone on Shock Reversal in Patients With Septic Shock.

ABSTRACT: In patients with septic shock, hydrocortisone 200-400 mg/d has been shown to reverse shock compared with placebo. Lower doses of hydrocortisone have not previously been studied, and there are no previous studies comparing two different doses of hydrocortisone. At our institution, some clinicians routinely prescribe doses less than 200 mg/d. This study aims to compare the effect of lower doses of hydrocortisone to standard doses on shock reversal and adverse events in septic shock.

Design

Retrospective cohort study.

Setting

Single-center medical ICU.

Subjects

Patients who received hydrocortisone for septic shock.

Interventions

Electronic chart review.

Measurements and main results

Patients were divided into low-dose hydrocortisone (75-150 mg/d) and standar

SUBMITTER: Sbertoli R 

PROVIDER: S-EPMC7188423 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature