Assessing the Course of Organ Dysfunction Using Joint Longitudinal and Time-to-Event Modeling in the Vasopressin and Septic Shock Trial.

ABSTRACT: Non-mortality septic shock outcomes (e.g., Sequential Organ Failure Assessment score) are important clinical endpoints in pivotal sepsis trials. However, comparisons of observed longitudinal non-mortality outcomes between study groups can be biased if death is unequal between study groups or is associated with an intervention (i.e., informative censoring). We compared the effects of vasopressin versus norepinephrine on the Sequential Organ Failure Assessment score in the Vasopressin and Septic Shock Trial to illustrate the use of joint modeling to help minimize potential bias from informative censoring.

Design

Secondary analysis of the Vasopressin and Septic Shock Trial data.

Setting

Twenty-seven ICUs in Canada, Australia, and United States.

Subjects

Seven hundred sixt

SUBMITTER: Harhay MO 

PROVIDER: S-EPMC7188432 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature