Impact of maternal obesity on placental transcriptome and morphology associated with fetal growth restriction in mice.
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ABSTRACT:
SUBMITTER: de Barros Mucci D
PROVIDER: S-EPMC7188669 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Publications
Impact of maternal obesity on placental transcriptome and morphology associated with fetal growth restriction in mice.
de Barros Mucci Daniela D Kusinski Laura C LC Wilsmore Phoebe P Loche Elena E Pantaleão Lucas C LC Ashmore Thomas J TJ Blackmore Heather L HL Fernandez-Twinn Denise S DS Carmo Maria das Graças T do MDGTD Ozanne Susan E SE
International journal of obesity (2005) 20200313 5
<h4>Background</h4>In utero exposure to obesity is consistently associated with increased risk of metabolic disease, obesity and cardiovascular dysfunction in later life despite the divergence of birth weight outcomes. The placenta plays a critical role in offspring development and long-term health, as it mediates the crosstalk between the maternal and fetal environments. However, its phenotypic and molecular modifications in the context of maternal obesity associated with fetal growth restricti ...[more]
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