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Structure-Functional Activity Relationship of ?-Glucans From the Perspective of Immunomodulation: A Mini-Review.

ABSTRACT: ?-Glucans are a heterogeneous group of glucose polymers with a common structure comprising a main chain of ?-(1,3) and/or ?-(1,4)-glucopyranosyl units, along with side chains with various branches and lengths. ?-Glucans initiate immune responses via immune cells, which become activated by the binding of the polymer to specific receptors. However, ?-glucans from different sources also differ in their structure, conformation, physical properties, binding affinity to receptors, and thus biological functions. The mechanisms behind this are not fully understood. This mini-review provides a comprehensive and up-to-date commentary on the relationship between ?-glucans' structure and function in relation to their use for immunomodulation.

SUBMITTER: Han B

PROVIDER: S-EPMC7188827 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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Structure-Functional Activity Relationship of β-Glucans From the Perspective of Immunomodulation: A Mini-Review.

Han Biao B Baruah Kartik K Cox Eric E Vanrompay Daisy D Bossier Peter P

Frontiers in immunology 20200422

β-Glucans are a heterogeneous group of glucose polymers with a common structure comprising a main chain of β-(1,3) and/or β-(1,4)-glucopyranosyl units, along with side chains with various branches and lengths. β-Glucans initiate immune responses via immune cells, which become activated by the binding of the polymer to specific receptors. However, β-glucans from different sources also differ in their structure, conformation, physical properties, binding affinity to receptors, and thus biological ...[more]

PMID: 32391005

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