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Effect of egg consumption on inflammatory markers: a systematic review and meta-analysis of randomized controlled clinical trials.

ABSTRACT: There is little evidence about whether eggs affect inflammation. The aim of this meta-analysis was to explore the effects of egg consumption on inflammation. A systematic search of online databases (Institute for Scientific Information (ISI), Scopus, Ovid, PubMed, Cochrane) was used to gather clinical trials that assessed the effect of egg consumption on circulating inflammatory biomarkers. Using a random-effects model, pooled weighted mean differences (WMD) and corresponding standard deviations (SD) were calculated. Of the 21 eligible studies found, nine trials were eligible for analysis. Eight trials assessed high-sensitivity C-reactive protein (hs-CRP), four trials assessed interleukin-6 (IL-6), and five trials assessed tumor necrosis factor-alpha (TNF-?). Egg consumption did not affect hs-CRP (WMD 0.24 mg/L; 95% CI: -0.43, 0.90; I2 = 53.8; P =?0.48), IL-6 (WMD 0.20 pg/mL; 95% CI: -0.71, 1.11; I2 =?69.3; P =?0.50), and TNF-? (WMD: -0.38 pg/mL; 95% CI: -0.87, 0.10; I2 =?0.00; P =?0.12) relative to controls. Overall, this meta-analysis revealed that egg consumption had no significant effect on serum biomarkers of inflammation in adults. © 2019 Society of Chemical Industry.

SUBMITTER: Sajadi Hezaveh Z

PROVIDER: S-EPMC7189602 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature

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Effect of egg consumption on inflammatory markers: a systematic review and meta-analysis of randomized controlled clinical trials.

Sajadi Hezaveh Zohreh Z Sikaroudi Masoumeh Khalighi MK Vafa Mohammadreza M Clayton Zachary Stephen ZS Soltani Sepideh S

Journal of the science of food and agriculture 20190930 15

There is little evidence about whether eggs affect inflammation. The aim of this meta-analysis was to explore the effects of egg consumption on inflammation. A systematic search of online databases (Institute for Scientific Information (ISI), Scopus, Ovid, PubMed, Cochrane) was used to gather clinical trials that assessed the effect of egg consumption on circulating inflammatory biomarkers. Using a random-effects model, pooled weighted mean differences (WMD) and corresponding standard deviations ...[more]

PMID: 31259415

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Project description:ObjectivesThe effectiveness of CytoSorb at removing inflammatory mediators in critically ill patients is controversial.Data sourcesElectronic databases were searched from inception to May 2023.Study selectionRandomized controlled trials reporting the effects of CytoSorb therapy on inflammatory parameters in critically ill patients with hyperinflammatory conditions were included.Data extractionTwo authors screened articles for eligibility, extracted data, and assessed the risk of bias, conflicts of interest, and certainty of evidence (CoE). The primary outcome was interleukin (IL)-6 at 1 day after initiation of the therapy. Secondary outcomes included various inflammatory markers at 1, 2, 3, and 5 days and mortality. Data were pooled if at least three trials reported the outcome of interest. We conducted meta-analyses of the data using a random-effects model.Data synthesisSeventeen trials (n = 855) were included. Fourteen trials were judged to have notable concern about conflicts of interest. Seven trials were performed in medical ICU patients with hyperinflammatory conditions and 10 in complex cardiovascular surgery under cardiopulmonary bypass. Hemoadsorption with CytoSorb was not associated with lower IL-6 at 1 day (mean difference -5.98 [95% CI, -30.44 to 18.48] pg/mL), 2 days, 3 days, or 5 days after initiation of the treatment, as well as the concentration of procalcitionin. The levels of C-reactive protein were not lower with CytoSorb at 1, 2, and 3 days. The use of CytoSorb was associated with higher mortality at latest follow-up (relative risk = 1.22 [95% CI, 1.02-1.45]) and at 30 days. CoE ranged from low to very low.ConclusionsThe use of CytoSorb hemoadsorption in a mixed population of critically ill patients with hyperinflammatory conditions does not exhibit a consistent decrease in IL-6 and other inflammatory parameters within the first 5 days of treatment. The significant uncertainty surrounding these findings highlights the need for further investigations.

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Effect of egg consumption on inflammatory markers: a systematic review and meta-analysis of randomized controlled clinical trials.

Publications

Effect of egg consumption on inflammatory markers: a systematic review and meta-analysis of randomized controlled clinical trials.

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