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Strong associations and moderate predictive value of early symptoms for SARS-CoV-2 test positivity among healthcare workers, the Netherlands, March 2020.


ABSTRACT: Healthcare workers (n?=?803) with mild symptoms were tested for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (n?=?90 positive) and asked to complete a symptom questionnaire. Anosmia, muscle ache, ocular pain, general malaise, headache, extreme tiredness and fever were associated with positivity. A predictive model based on these symptoms showed moderate discriminative value (sensitivity: 91.2%; specificity: 55.6%). While our models would not justify presumptive SARS-CoV-2 diagnosis without molecular confirmation, it can contribute to targeted screening strategies.

SUBMITTER: Tostmann A 

PROVIDER: S-EPMC7189649 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature

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Strong associations and moderate predictive value of early symptoms for SARS-CoV-2 test positivity among healthcare workers, the Netherlands, March 2020.

Tostmann Alma A   Bradley John J   Bousema Teun T   Yiek Wing-Kee WK   Holwerda Minke M   Bleeker-Rovers Chantal C   Ten Oever Jaap J   Meijer Corianne C   Rahamat-Langendoen Janette J   Hopman Joost J   van der Geest-Blankert Nannet N   Wertheim Heiman H  

Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin 20200401 16


Healthcare workers (n = 803) with mild symptoms were tested for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (n = 90 positive) and asked to complete a symptom questionnaire. Anosmia, muscle ache, ocular pain, general malaise, headache, extreme tiredness and fever were associated with positivity. A predictive model based on these symptoms showed moderate discriminative value (sensitivity: 91.2%; specificity: 55.6%). While our models would not justify presumptive SARS-CoV-2 diagnos  ...[more]

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