Plasma proteomic signature of the risk of developing mobility disability: A 9-year follow-up.

ABSTRACT:

Introduction

Mobility disability is a powerful indicator of poor health in older adults. The biological and pathophysiological mechanism underlying the development of mobility disability remains unknown. This study conducted a data-driven discovery phase investigation to identify plasma proteins that predict the incidence of mobility disability in community-dwelling older adults without mobility disability at baseline.

Methods

We investigated 660 women and men, aged 71.9 ± 6.0 (60-94) years, who participated in the Invecchiare in Chianti, "Aging in the Chianti Area" study and completed the 400-m walk at fast pace (400-m walk) at enrollment. Median follow-up time was 8.57 [interquartile, 3.20-9.08] years. SOMAscan technology was used to measure 1,301 plasma proteins at enroll

SUBMITTER: Osawa Y 

PROVIDER: S-EPMC7189986 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature