Opioid agonist treatment and risk of mortality during opioid overdose public health emergency: population based retrospective cohort study.

ABSTRACT:

Objective

To compare the risk of mortality among people with opioid use disorder on and off opioid agonist treatment (OAT) in a setting with a high prevalence of illicitly manufactured fentanyl and other potent synthetic opioids in the illicit drug supply.

Design

Population based retrospective cohort study.

Setting

Individual level linkage of five health administrative datasets capturing drug dispensations, hospital admissions, physician billing records, ambulatory care reports, and deaths in British Columbia, Canada.

Participants

55 347 people with opioid use disorder who received OAT between 1 January 1996 and 30 September 2018.

Main outcome measures

All cause and cause specific crude mortality rates (per 1000 person years) to determine absolute risk o

SUBMITTER: Pearce LA 

PROVIDER: S-EPMC7190018 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature