Dataset Information

Birth month, birth season, and overall and cardiovascular disease mortality in US women: prospective cohort study.

ABSTRACT:

Objectives

To evaluate the associations between birth month, birth season, and overall and cardiovascular disease mortality, and to examine the role of familial and socioeconomic factors in these associations.

Design

Prospective cohort study.

Setting

Nurses' Health Study, established in 1976, an ongoing prospective cohort study in the United States.

Participants

Female registered nurses who reported information on date of birth at study enrolment (n=116?911, 1976-2014, followed for 38 years).

Exposure

Birth month and astronomical birth season (based on solstices and equinoxes as boundaries of the season categories).

Main outcome measures

Age and various multivariable adjusted hazard ratios and 95% confidence intervals for the association between birth months (using November as the reference), astronomical birth season (using autumn as the reference), and overall and cardiovascular disease specific mortality were assessed using Cox proportional hazards models.

Results

Among study participants, 43?248 overall deaths were documented during 4?136?364 person years of follow-up since enrolment, including 8360 cardiovascular disease related deaths. In fully adjusted multivariable analyses, no significant association was observed between birth month, birth season, and overall mortality. Compared with women born in November, increased cardiovascular disease mortality was observed among those born from March to July (hazard ratio for March, 1.09, 95% confidence interval 0.98 to 1.21; April, 1.12, 1.00 to 1.24; May, 1.08, 0.98 to 1.20; June, 1.07, 0.96 to 1.19; and July 1.08, 0.98 to 1.20). Those born in April had the highest cardiovascular disease mortality, and those born in December had the lowest (December, 0.95, 0.85 to 1.06). The relative difference between the lowest and highest risk month was 17.89%. Women born in spring (1.10, 1.04 to 1.17) and summer (1.09, 1.03 to 1.16) had a higher cardiovascular disease mortality than women born in the autumn. Adjustment for familial and socioeconomic factors did not change these results. The relative difference between the lowest and highest risk season was 10.00%.

Conclusion

Participants born in the spring and summer (especially those born in March-July) had a slight but significant increase in cardiovascular disease specific mortality. However, no seasonal birth month effect was observed among women for overall mortality. Familial and socioeconomic factors did not appear to alter these associations. Further studies are required to confirm these findings and reveal mechanisms of these seasonal birth month effects in cardiovascular disease mortality.

SUBMITTER: Zhang Y

PROVIDER: S-EPMC7190053 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Birth month, birth season, and overall and cardiovascular disease mortality in US women: prospective cohort study.

Zhang Yin Y Devore Elizabeth E EE Strohmaier Susanne S Grodstein Francine F Schernhammer Eva S ES

BMJ (Clinical research ed.) 20191218

<h4>Objectives</h4>To evaluate the associations between birth month, birth season, and overall and cardiovascular disease mortality, and to examine the role of familial and socioeconomic factors in these associations.<h4>Design</h4>Prospective cohort study.<h4>Setting</h4>Nurses' Health Study, established in 1976, an ongoing prospective cohort study in the United States.<h4>Participants</h4>Female registered nurses who reported information on date of birth at study enrolment (n=116 911, 1976-201 ...[more]

PMID: 31852664

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Dataset Information

Birth month, birth season, and overall and cardiovascular disease mortality in US women: prospective cohort study.

Objectives

Design

Setting

Participants

Exposure

Main outcome measures

Results

Conclusion

Publications

Birth month, birth season, and overall and cardiovascular disease mortality in US women: prospective cohort study.

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