Updating insights into rosiglitazone and cardiovascular risk through shared data: individual patient and summary level meta-analyses.
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ABSTRACT:
SUBMITTER: Wallach JD
PROVIDER: S-EPMC7190063 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Publications
Updating insights into rosiglitazone and cardiovascular risk through shared data: individual patient and summary level meta-analyses.
Wallach Joshua D JD Wang Kun K Zhang Audrey D AD Cheng Deanna D Grossetta Nardini Holly K HK Lin Haiqun H Bracken Michael B MB Desai Mayur M Krumholz Harlan M HM Ross Joseph S JS
BMJ (Clinical research ed.) 20200205
<h4>Objectives</h4>To conduct a systematic review and meta-analysis of the effects of rosiglitazone treatment on cardiovascular risk and mortality using multiple data sources and varying analytical approaches with three aims in mind: to clarify uncertainties about the cardiovascular risk of rosiglitazone; to determine whether different analytical approaches are likely to alter the conclusions of adverse event meta-analyses; and to inform efforts to promote clinical trial transparency and data sh ...[more]
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