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The Impact of Obesity on Tumor Glucose Uptake in Breast and Lung Cancer.

ABSTRACT: Obesity confers an increased incidence and poorer clinical prognosis in more than 10 cancer types. Paradoxically, obesity may provide protection from poor outcomes in lung cancer. Mechanisms for the obesity-cancer links are not fully elucidated, with altered glucose metabolism being a promising candidate. Using 18F-fluorodeoxyglucose positron-emission-tomography/computed tomography images from The Cancer Imaging Archive, we explored the relationship between body mass index (BMI) and glucose metabolism in several cancers. In 188 patients (BMI mean [SD] = 27.7 [5.1], range = 17.4-49.3?kg/m2), higher BMI was associated with greater tumor glucose uptake in breast cancer (r?=?0.36; P?=?.02) and with lower tumor glucose uptake in non-small cell lung cancer (r = -0.26; P?=?.048) using two-sided Pearson correlations. No relationship was observed in soft tissue sarcoma or squamous cell carcinoma. Harnessing the National Cancer Institute's open-access database, we demonstrate altered tumor glucose metabolism as a potential mechanism for the detrimental and protective effects of obesity on breast and lung cancer, respectively.

SUBMITTER: Leitner BP

PROVIDER: S-EPMC7190208 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature

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The Impact of Obesity on Tumor Glucose Uptake in Breast and Lung Cancer.

Leitner Brooks P BP Perry Rachel J RJ

JNCI cancer spectrum 20200212 2

Obesity confers an increased incidence and poorer clinical prognosis in more than 10 cancer types. Paradoxically, obesity may provide protection from poor outcomes in lung cancer. Mechanisms for the obesity-cancer links are not fully elucidated, with altered glucose metabolism being a promising candidate. Using 18F-fluorodeoxyglucose positron-emission-tomography/computed tomography images from The Cancer Imaging Archive, we explored the relationship between body mass index (BMI) and glucose meta ...[more]

PMID: 32368718

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The Impact of Obesity on Tumor Glucose Uptake in Breast and Lung Cancer.

Publications

The Impact of Obesity on Tumor Glucose Uptake in Breast and Lung Cancer.

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