Immune-based therapies for hepatocellular carcinoma.
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ABSTRACT:
SUBMITTER: Pinato DJ
PROVIDER: S-EPMC7190571 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Publications
Immune-based therapies for hepatocellular carcinoma.
Pinato David J DJ Guerra Nadia N Fessas Petros P Murphy Ravindhi R Mineo Takashi T Mauri Francesco A FA Mukherjee Sujit K SK Thursz Mark M Wong Ching Ngar CN Sharma Rohini R Rimassa Lorenza L
Oncogene 20200310 18
Hepatocellular carcinoma (HCC) is the third most frequent cause of cancer-related death. The immune-rich contexture of the HCC microenvironment makes this tumour an appealing target for immune-based therapies. Here, we discuss how the functional characteristics of the liver microenvironment can potentially be harnessed for the treatment of HCC. We will review the evidence supporting a therapeutic role for vaccines, cell-based therapies and immune-checkpoint inhibitors and discuss the potential f ...[more]
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