Dataset Information

Ability of the post-operative ALBI grade to predict the outcomes of hepatocellular carcinoma after curative surgery.

ABSTRACT: The albumin-bilirubin (ALBI) grade has been validated as a significant predictor for hepatocellular carcinoma (HCC). However, there is little information about the impact of postoperative ALBI grade in patients with HCC who are undergoing liver resection. We enrolled 525 HCC patients who received primary resection from April 2001 to March 2017. The impact of the pre- and post-operative ALBI grades on overall survival (OS) and recurrence-free survival (RFS) were analyzed by multivariate analysis. During the follow-up period (mean, 65 months), 253 (48.1%) patients experienced recurrence, and 85 (16.2%) patients died. Multivariate analysis revealed that diabetes mellitus (DM) (p?=?0.011), alpha-fetoprotein levels (AFP) (p?

SUBMITTER: Cho WR

PROVIDER: S-EPMC7190718 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature

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Ability of the post-operative ALBI grade to predict the outcomes of hepatocellular carcinoma after curative surgery.

Cho Wei-Ru WR Hung Chao-Hung CH Chen Chien-Hung CH Lin Chih-Che CC Wang Chih-Chi CC Liu Yueh-Wei YW Wu Yi-Ju YJ Yong Chee-Chien CC Chen Kuang-Den KD Tsai Yu-Chieh YC Hu Tsung-Hui TH Tsai Ming-Chao MC

Scientific reports 20200429 1

The albumin-bilirubin (ALBI) grade has been validated as a significant predictor for hepatocellular carcinoma (HCC). However, there is little information about the impact of postoperative ALBI grade in patients with HCC who are undergoing liver resection. We enrolled 525 HCC patients who received primary resection from April 2001 to March 2017. The impact of the pre- and post-operative ALBI grades on overall survival (OS) and recurrence-free survival (RFS) were analyzed by multivariate analysis. ...[more]

PMID: 32350365

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Project description:BACKGROUND: Surgical resection is one important curative treatment for hepatocellular carcinoma (HCC), but the prognosis following surgery differs substantially and such large variation is mainly unexplained. A review of the literature yields a number of clinicopathologic parameters associated with HCC prognosis. However, the results are not consistent due to lack of systemic approach to establish a prediction model incorporating all these parameters. METHODS: We conducted a retrospective analysis on the common clinicopathologic parameters from a cohort of 572 ethnic Chinese HCC patients who received curative surgery. The cases were randomly divided into training (n = 272) and validation (n = 300) sets. Each parameter was individually tested and the significant parameters were entered into a linear classifier for model building, and the prediction accuracy was assessed in the validation set RESULTS: Our findings based on the training set data reveal 6 common clinicopathologic parameters (tumor size, number of tumor nodules, tumor stage, venous infiltration status, and serum alpha-fetoprotein and total albumin levels) that were significantly associated with the overall HCC survival and disease-free survival (time to recurrence). We next built a linear classifier model by multivariate Cox regression to predict prognostic outcomes of HCC patients after curative surgery This analysis detected a considerable fraction of variance in HCC prognosis and the area under the ROC curve was about 70%. We further evaluated the model using two other protocols; leave-one-out procedure (n = 264) and independent validation (n = 300). Both were found to have excellent prediction power. The predicted score could separate patients into distinct groups with respect to survival (p-value = 1.8e-12) and disease free survival (p-value = 3.2e-7). CONCLUSION: This described model will provide valuable guidance on prognosis after curative surgery for HCC in clinical practice. The adaptive nature allows easy accommodation for future new biomarker inputs, and it may serve as the foundation for future modeling and prediction for HCC prognosis after surgical treatment.

Dataset Information

Ability of the post-operative ALBI grade to predict the outcomes of hepatocellular carcinoma after curative surgery.

Publications

Ability of the post-operative ALBI grade to predict the outcomes of hepatocellular carcinoma after curative surgery.

Similar Datasets

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