Ontology highlight
ABSTRACT:
SUBMITTER: Watteyne J
PROVIDER: S-EPMC7190830 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Nature communications 20200429 1
Learning and memory are regulated by neuromodulatory pathways, but the contribution and temporal requirement of most neuromodulators in a learning circuit are unknown. Here we identify the evolutionarily conserved neuromedin U (NMU) neuropeptide family as a regulator of C. elegans gustatory aversive learning. The NMU homolog CAPA-1 and its receptor NMUR-1 are required for the retrieval of learned salt avoidance. Gustatory aversive learning requires the release of CAPA-1 neuropeptides from sensor ...[more]