Substance P Improves Renal Ischemia Reperfusion Injury Through Modulating Immune Response.
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ABSTRACT:
SUBMITTER: Kim DJ
PROVIDER: S-EPMC7190869 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
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Substance P Improves Renal Ischemia Reperfusion Injury Through Modulating Immune Response.
Kim Dong-Jin DJ Moon Ju-Young JY Kim Su-Mi SM Seo Jung-Woo JW Lee Yu Ho YH Jung Su Woong SW Kim Kipyo K Kim Yang Gyun YG Lim Sung-Jig SJ Lee Sangju S Son Youngsook Y Lee Sang-Ho SH
Frontiers in immunology 20200423
Substance P (SP), an injury-inducible messenger that mobilizes bone marrow stem cells and modulates the immune response, has been suggested as a novel target for therapeutic agents. We evaluated the role of SP as an immune cell modulator during the progression of renal ischemic/reperfusion injury (IRI). Unilateral IRI induced the transient expression of endogenous SP and the infiltration of CCR7<sup>+</sup> M1 macrophages in injured kidneys. However, SP altered the intrarenal macrophage polariza ...[more]
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