Ontology highlight
ABSTRACT:
SUBMITTER: Li J
PROVIDER: S-EPMC7190935 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
The Journal of clinical investigation 20200501 5
Whether mutations in cancer driver genes directly affect cancer immune phenotype and T cell immunity remains a standing question. ARID1A is a core member of the polymorphic BRG/BRM-associated factor chromatin remodeling complex. ARID1A mutations occur in human cancers and drive cancer development. Here, we studied the molecular, cellular, and clinical impact of ARID1A aberrations on cancer immunity. We demonstrated that ARID1A aberrations resulted in limited chromatin accessibility to IFN-respon ...[more]