Unknown

Dataset Information

0

Non-invasive Transdermal Delivery of Human Insulin Using Ionic Liquids: In vitro Studies.

ABSTRACT: In this research project, synthesis and characterization of ionic liquids and their subsequent utilization as facilitators of transdermal delivery of human insulin was pursued. Choline geranate and choline oleate ionic liquids (and their deep eutectic solvents) were produced and characterized by nuclear magnetic resonance (1H NMR), water content, oxidative stability, cytotoxicity and genotoxicity assays, and ability to promote transdermal protein permeation. The results gathered clearly suggest that all ionic liquids were able to promote/facilitate transdermal permeation of insulin, although to various extents. In particular, choline geranate 1:2 combined with its virtually nil cyto- and geno-toxicity was chosen to be incorporated in a biopolymeric formulation making it a suitable facilitator aiming at transdermal delivery of insulin.

SUBMITTER: Jorge LR 

PROVIDER: S-EPMC7191306 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

Non-invasive Transdermal Delivery of Human Insulin Using Ionic Liquids: <i>In vitro</i> Studies.

Jorge Ludmilla R LR   Harada Liliam K LK   Silva Erica C EC   Campos Welida F WF   Moreli Fernanda C FC   Shimamoto Gustavo G   Pereira Jorge F B JFB   Oliveira José M JM   Tubino Matthieu M   Vila Marta M D C MMDC   Balcão Victor M VM  

Frontiers in pharmacology 20200423

In this research project, synthesis and characterization of ionic liquids and their subsequent utilization as facilitators of transdermal delivery of human insulin was pursued. Choline geranate and choline oleate ionic liquids (and their deep eutectic solvents) were produced and characterized by nuclear magnetic resonance (<sup>1</sup>H NMR), water content, oxidative stability, cytotoxicity and genotoxicity assays, and ability to promote transdermal protein permeation. The results gathered clear  ...[more]

Similar Datasets

Unknown Ionic liquids for oral insulin delivery.
| S-EPMC6048483 | biostudies-literature
Unknown Ionic liquids as a class of materials for transdermal delivery and pathogen neutralization.
| S-EPMC4169946 | biostudies-literature
Unknown Solubility Studies of Cyclosporine Using Ionic Liquids.
| S-EPMC6649182 | biostudies-literature
Unknown Advances in transdermal insulin delivery.
| S-EPMC6556146 | biostudies-literature
Unknown Upgrading the Topical Delivery of Poorly Soluble Drugs Using Ionic Liquids as a Versatile Tool.
| S-EPMC8122351 | biostudies-literature
Transcriptomics Transcriptional toxicity of imidazolium- and cholinium-based ionic liquids
2021-08-13 | GSE156769 | GEO
Unknown Transdermal Bioavailability in Rats of Lidocaine in the Forms of Ionic Liquids, Salts, and Deep Eutectic.
| S-EPMC5430390 | biostudies-literature
Unknown Non-transdermal microneedles for advanced drug delivery.
| S-EPMC7295684 | biostudies-literature
Unknown Evaluation of Heat Effects on Fentanyl Transdermal Delivery Systems Using In Vitro Permeation and In Vitro Release Methods.
| S-EPMC7644256 | biostudies-literature
Unknown In Vitro Evaluation of Self-Nano-Emulsifying Drug Delivery Systems (SNEDDS) Containing Room Temperature Ionic Liquids (RTILs) for the Oral Delivery of Amphotericin B.
| S-EPMC7463809 | biostudies-literature