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Non-invasive Transdermal Delivery of Human Insulin Using Ionic Liquids: In vitro Studies.

ABSTRACT: In this research project, synthesis and characterization of ionic liquids and their subsequent utilization as facilitators of transdermal delivery of human insulin was pursued. Choline geranate and choline oleate ionic liquids (and their deep eutectic solvents) were produced and characterized by nuclear magnetic resonance (1H NMR), water content, oxidative stability, cytotoxicity and genotoxicity assays, and ability to promote transdermal protein permeation. The results gathered clearly suggest that all ionic liquids were able to promote/facilitate transdermal permeation of insulin, although to various extents. In particular, choline geranate 1:2 combined with its virtually nil cyto- and geno-toxicity was chosen to be incorporated in a biopolymeric formulation making it a suitable facilitator aiming at transdermal delivery of insulin.

SUBMITTER: Jorge LR 

PROVIDER: S-EPMC7191306 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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Non-invasive Transdermal Delivery of Human Insulin Using Ionic Liquids: <i>In vitro</i> Studies.

Jorge Ludmilla R LR   Harada Liliam K LK   Silva Erica C EC   Campos Welida F WF   Moreli Fernanda C FC   Shimamoto Gustavo G   Pereira Jorge F B JFB   Oliveira José M JM   Tubino Matthieu M   Vila Marta M D C MMDC   Balcão Victor M VM  

Frontiers in pharmacology 20200423

In this research project, synthesis and characterization of ionic liquids and their subsequent utilization as facilitators of transdermal delivery of human insulin was pursued. Choline geranate and choline oleate ionic liquids (and their deep eutectic solvents) were produced and characterized by nuclear magnetic resonance (<sup>1</sup>H NMR), water content, oxidative stability, cytotoxicity and genotoxicity assays, and ability to promote transdermal protein permeation. The results gathered clear  ...[more]

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