Ontology highlight
ABSTRACT:
SUBMITTER: Bartlett PJ
PROVIDER: S-EPMC7191650 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Bartlett Paula J PJ Cloete Ielyaas I Sneyd James J Thomas Andrew P AP
iScience 20200413 5
Ca<sup>2+</sup> oscillations that depend on inositol-1,4,5-trisphosphate (IP<sub>3</sub>) have been ascribed to biphasic Ca<sup>2+</sup> regulation of the IP<sub>3</sub> receptor (IP<sub>3</sub>R) or feedback mechanisms controlling IP<sub>3</sub> levels in different cell types. IP<sub>3</sub> uncaging in hepatocytes elicits Ca<sup>2+</sup> transients that are often localized at the subcellular level and increase in magnitude with stimulus strength. However, this does not reproduce the broad base ...[more]