Ontology highlight
ABSTRACT:
SUBMITTER: Moreno-Eutimio MA
PROVIDER: S-EPMC7192074 | biostudies-literature | 2020 May - Jun
REPOSITORIES: biostudies-literature
Moreno-Eutimio Mario Adán MA López-Macías Constantino C Pastelin-Palacios Rodolfo R
Microbes and infection 20200430 4-5
During virus infection, host toll-like receptors (TLRs) can recognize different pathogen-associated molecular patterns and trigger the innate immune response. TLR7/8 can identify the single-stranded RNA (ssRNA) of the virus. This study aimed to search ssRNA sequences recognized by TLR7/8 from the SARS-CoV-2, SARS-CoV, and MERS-CoV whole genomes by a bioinformatic technique. The immunoinformatic approach showed that the SARS-CoV-2 genome has more ssRNA fragments that could be recognized by TLR7/8 ...[more]