An implantable multifunctional neural microprobe for simultaneous multi-analyte sensing and chemical delivery.
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ABSTRACT: A multifunctional chemical neural probe fabrication process exploiting PDMS thin-film transfer to incorporate a microfluidic channel onto a silicon-based microelectrode array (MEA) platform, and enzyme microstamping to provide multi-analyte detection is described. The Si/PDMS hybrid chemtrode, modified with a nano-based on-probe IrOx reference electrode, was validated in brain phantoms and in rat brain.
SUBMITTER: Wang B
PROVIDER: S-EPMC7192313 | biostudies-literature |
REPOSITORIES: biostudies-literature
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