An implantable multifunctional neural microprobe for simultaneous multi-analyte sensing and chemical delivery.

ABSTRACT: A multifunctional chemical neural probe fabrication process exploiting PDMS thin-film transfer to incorporate a microfluidic channel onto a silicon-based microelectrode array (MEA) platform, and enzyme microstamping to provide multi-analyte detection is described. The Si/PDMS hybrid chemtrode, modified with a nano-based on-probe IrOx reference electrode, was validated in brain phantoms and in rat brain.

SUBMITTER: Wang B 

PROVIDER: S-EPMC7192313 | biostudies-literature |

REPOSITORIES: biostudies-literature