Validation of Salivary Markers, IL-1?, IL-8 and Lgals3bp for Detection of Oral Squamous Cell Carcinoma in an Indian Population.

ABSTRACT: Early detection and easier follow-up of oral squamous cell carcinoma (OSCC) would significantly improve the morbidity and mortality associated with it. With newer technologies, it has become possible to validate cancer biomarkers in saliva with high sensitivity and specificity. There is however a need to further validate these biomarkers in cohorts of different ethnic groups. Our objective was to validate previously evaluated salivary biomarkers in Indian population. The study enrolled 117 patients. These were grouped into subcatergories of 31 early (TNMstage I-II) and 27 late-stage OSCC (TNM stage III-IV), 30 PMOD and 29 post-treatment patients. There were 42 control subjects. We evaluated 3 protein markers, IL-1?, IL-8 and LGALS3BP using ELISA, from unstimulated saliva samples. Statistical analysis was done to calculate p-value, ROC, AUC, sensitivity, and specificity. Protein markers IL-1? and IL-8 were significantly elevated (p?

SUBMITTER: Singh P 

PROVIDER: S-EPMC7192911 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature