Ontology highlight
ABSTRACT:
SUBMITTER: Buchwald ZS
PROVIDER: S-EPMC7192941 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Buchwald Zachary S ZS Tian Sibo S Rossi Michael M Smith Geoffrey H GH Switchenko Jeffrey J Hauenstein Jennifer E JE Moreno Carlos S CS Press Robert H RH Prabhu Roshan S RS Zhong Jim J Saxe Debra F DF Neill Stewart G SG Olson Jeffrey J JJ Crocker Ian R IR Curran Walter J WJ Shu Hui-Kuo G HG
Scientific reports 20200430 1
Allele-specific copy number analysis of tumors (ASCAT) assesses copy number variations (CNV) while accounting for aberrant cell fraction and tumor ploidy. We evaluated if ASCAT-assessed CNV are associated with survival outcomes in 56 patients with WHO grade IV gliomas. Tumor data analyzed by Affymetrix OncoScan FFPE Assay yielded the log ratio (R) and B-allele frequency (BAF). Input into ASCAT quantified CNV using the segmentation function to measure copy number inflection points throughout the ...[more]