Tumor Plasticity and Resistance to Immunotherapy.
Ontology highlight
ABSTRACT:
SUBMITTER: Horn LA
PROVIDER: S-EPMC7192950 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Publications
Tumor Plasticity and Resistance to Immunotherapy.
Horn Lucas A LA Fousek Kristen K Palena Claudia C
Trends in cancer 20200304 5
Tumor cell plasticity exhibited as an epithelial-mesenchymal transition (EMT) has been identified as a major obstacle for the effective treatment of many cancers. This process, which involves the dedifferentiation of epithelial tumor cells towards a motile, metastatic, and mesenchymal tumor phenotype, mediates resistance to conventional therapies and small-molecule targeted therapies. In this review, we highlight current research correlating the role of tumor plasticity with resistance to curren ...[more]
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