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Production of Terpenoids by Synthetic Biology Approaches.

ABSTRACT: Terpenoids are a large family of natural products with remarkable diverse biological functions, and have a wide range of applications as pharmaceuticals, flavors, pigments, and biofuels. Synthetic biology is presenting possibilities for sustainable and efficient production of high value-added terpenoids in engineered microbial cell factories, using Escherichia coli and Saccharomyces cerevisiae which are identified as well-known industrial workhorses. They also provide a promising alternative to produce non-native terpenes on account of available genetic tools in metabolic engineering and genome editing. In this review, we summarize the recent development in terpenoids production by synthetic biology approaches.

SUBMITTER: Zhang C

PROVIDER: S-EPMC7193017 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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Production of Terpenoids by Synthetic Biology Approaches.

Zhang Caizhe C Hong Kui K

Frontiers in bioengineering and biotechnology 20200424

Terpenoids are a large family of natural products with remarkable diverse biological functions, and have a wide range of applications as pharmaceuticals, flavors, pigments, and biofuels. Synthetic biology is presenting possibilities for sustainable and efficient production of high value-added terpenoids in engineered microbial cell factories, using <i>Escherichia coli</i> and <i>Saccharomyces cerevisiae</i> which are identified as well-known industrial workhorses. They also provide a promising a ...[more]

PMID: 32391346

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