Ontology highlight
ABSTRACT:
SUBMITTER: Cheng Z
PROVIDER: S-EPMC7193024 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Cheng Zhongyi Z Xia Yuanyuan Y Zhou Zhemin Z
Frontiers in bioengineering and biotechnology 20200424
Nitrile hydratase (NHase, EC 4.2.1.84) is one type of metalloenzyme participating in the biotransformation of nitriles into amides. Given its catalytic specificity in amide production and eco-friendliness, NHase has overwhelmed its chemical counterpart during the past few decades. However, unclear catalytic mechanism, low thermostablity, and narrow substrate specificity limit the further application of NHase. During the past few years, numerous studies on the theoretical and industrial aspects o ...[more]